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The Effect of ethanol Psidium Guava leaf extract on KCl Induced Contracted Aortic tissues of Guinea Pigs

Received: 2 January 2017     Accepted: 17 January 2017     Published: 16 February 2017
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Abstract

Hypertension is elevation of systolic blood pressure greater than or equal to 140 mm Hg and/or diastolic blood pressure greater than or equal to 90 mm Hg. It affects 1 billion people and accounts for approximately 7.1 million deaths annually. It is significant risk factor for cardiovascular disorders. Some medicinal plants are traditionally used to treat hypertension. Psidium guava is one of widely cultivated medicinal plant used as traditional medication for diabetes, vomiting, diarrhea and dyslipidemia. The study was designed to identify effect of P. guava leaf extract on hypertension in guinea pigs. The study was conducted on six male guinea pigs to measure the effect of ethanol P. guava leaf extract by using invasive method. The result was analyzed by using paired t-test, independent student t test, one –way ANOVA. Ethanol extract of P. guava leaf showed a significant (p= 0.001) ability to relax isolated aortic tissue of guinea pigs in dose dependent manner, after induction of aortic muscle contraction by high potassium chloride concentrations (80 mM KCl). The effects of P. guava leaf extract in relaxation contracted aortic tissue was may be due to numerous effect of phytochemicals.

Published in Journal of Diseases and Medicinal Plants (Volume 3, Issue 1)
DOI 10.11648/j.jdmp.20170301.12
Page(s) 7-11
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Aortic Tissue, Blood Pressure, Cardiovascular Diseases, Effect, Extract, Guinea Pigs, Hypertension, P. Guava

References
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  • APA Style

    Abayneh Elias, Daniel Seifu, Frank Ashall, Tesfaye Tolessa. (2017). The Effect of ethanol Psidium Guava leaf extract on KCl Induced Contracted Aortic tissues of Guinea Pigs. Journal of Diseases and Medicinal Plants, 3(1), 7-11. https://doi.org/10.11648/j.jdmp.20170301.12

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    ACS Style

    Abayneh Elias; Daniel Seifu; Frank Ashall; Tesfaye Tolessa. The Effect of ethanol Psidium Guava leaf extract on KCl Induced Contracted Aortic tissues of Guinea Pigs. J. Dis. Med. Plants 2017, 3(1), 7-11. doi: 10.11648/j.jdmp.20170301.12

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    AMA Style

    Abayneh Elias, Daniel Seifu, Frank Ashall, Tesfaye Tolessa. The Effect of ethanol Psidium Guava leaf extract on KCl Induced Contracted Aortic tissues of Guinea Pigs. J Dis Med Plants. 2017;3(1):7-11. doi: 10.11648/j.jdmp.20170301.12

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  • @article{10.11648/j.jdmp.20170301.12,
      author = {Abayneh Elias and Daniel Seifu and Frank Ashall and Tesfaye Tolessa},
      title = {The Effect of ethanol Psidium Guava leaf extract on KCl Induced Contracted Aortic tissues of Guinea Pigs},
      journal = {Journal of Diseases and Medicinal Plants},
      volume = {3},
      number = {1},
      pages = {7-11},
      doi = {10.11648/j.jdmp.20170301.12},
      url = {https://doi.org/10.11648/j.jdmp.20170301.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20170301.12},
      abstract = {Hypertension is elevation of systolic blood pressure greater than or equal to 140 mm Hg and/or diastolic blood pressure greater than or equal to 90 mm Hg. It affects 1 billion people and accounts for approximately 7.1 million deaths annually. It is significant risk factor for cardiovascular disorders. Some medicinal plants are traditionally used to treat hypertension. Psidium guava is one of widely cultivated medicinal plant used as traditional medication for diabetes, vomiting, diarrhea and dyslipidemia. The study was designed to identify effect of P. guava leaf extract on hypertension in guinea pigs. The study was conducted on six male guinea pigs to measure the effect of ethanol P. guava leaf extract by using invasive method. The result was analyzed by using paired t-test, independent student t test, one –way ANOVA. Ethanol extract of P. guava leaf showed a significant (p= 0.001) ability to relax isolated aortic tissue of guinea pigs in dose dependent manner, after induction of aortic muscle contraction by high potassium chloride concentrations (80 mM KCl). The effects of P. guava leaf extract in relaxation contracted aortic tissue was may be due to numerous effect of phytochemicals.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - The Effect of ethanol Psidium Guava leaf extract on KCl Induced Contracted Aortic tissues of Guinea Pigs
    AU  - Abayneh Elias
    AU  - Daniel Seifu
    AU  - Frank Ashall
    AU  - Tesfaye Tolessa
    Y1  - 2017/02/16
    PY  - 2017
    N1  - https://doi.org/10.11648/j.jdmp.20170301.12
    DO  - 10.11648/j.jdmp.20170301.12
    T2  - Journal of Diseases and Medicinal Plants
    JF  - Journal of Diseases and Medicinal Plants
    JO  - Journal of Diseases and Medicinal Plants
    SP  - 7
    EP  - 11
    PB  - Science Publishing Group
    SN  - 2469-8210
    UR  - https://doi.org/10.11648/j.jdmp.20170301.12
    AB  - Hypertension is elevation of systolic blood pressure greater than or equal to 140 mm Hg and/or diastolic blood pressure greater than or equal to 90 mm Hg. It affects 1 billion people and accounts for approximately 7.1 million deaths annually. It is significant risk factor for cardiovascular disorders. Some medicinal plants are traditionally used to treat hypertension. Psidium guava is one of widely cultivated medicinal plant used as traditional medication for diabetes, vomiting, diarrhea and dyslipidemia. The study was designed to identify effect of P. guava leaf extract on hypertension in guinea pigs. The study was conducted on six male guinea pigs to measure the effect of ethanol P. guava leaf extract by using invasive method. The result was analyzed by using paired t-test, independent student t test, one –way ANOVA. Ethanol extract of P. guava leaf showed a significant (p= 0.001) ability to relax isolated aortic tissue of guinea pigs in dose dependent manner, after induction of aortic muscle contraction by high potassium chloride concentrations (80 mM KCl). The effects of P. guava leaf extract in relaxation contracted aortic tissue was may be due to numerous effect of phytochemicals.
    VL  - 3
    IS  - 1
    ER  - 

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Author Information
  • Department of Biological Sciences, Dire Dawa University, Dire Dawa, Ethiopia

  • Department of Medical Biochemistry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia

  • Department of Medical Biochemistry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia

  • Department of Medical Physiology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia

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