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Evaluation of Breast Neoplastic Lesions by Different Cytology Grading Methods

Received: 22 June 2015     Accepted: 23 June 2015     Published: 3 August 2015
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Abstract

Introduction: With the increase in the awareness of breast cancer among women, cases of lump in the breast has increased in outpatient department. Fine needle aspiration cytology (FNAC) is the easy, quick and cost effective technique of evaluating breast lump. Objective: The present study, evaluated and compared the modified Masood's cytology index (MCI) with various other cytology grading methods and histopathology. Result: Modified MCI has over all concordance rate of 86%, sensitivity of 86%, specificity of 50%, positive predictive value (PPV) of 93% and negative predictive value (NPV) of 30%. Multiple regression analysis revealed an r2 value of 60%, which was significant. The p-value of anisonucleosis, nucleoli and chromatin pattern were 0.001, 0.05 and 0.02 respectively, which was significant (p-value less than 0.05). Conclusion: Modified MCI will help the cytopathologist to accurately delineate both benign and malignant neoplastic breast lesions into respective categories. This in turn will help the treating surgeon to plan the treatment modality of the patients with lump in the breast. The study recommends that modified MCI method to be routinely incorporated for evaluation of all lump in the breast.

Published in Science Journal of Clinical Medicine (Volume 4, Issue 4-1)

This article belongs to the Special Issue Latest Different Concepts of Gynaecology

DOI 10.11648/j.sjcm.s.2015040401.17
Page(s) 26-30
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Breast, Masood Cytology Index, FNAC, Cytology

References
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  • APA Style

    T. S. Rekha, N. M. Nandini. (2015). Evaluation of Breast Neoplastic Lesions by Different Cytology Grading Methods. Science Journal of Clinical Medicine, 4(4-1), 26-30. https://doi.org/10.11648/j.sjcm.s.2015040401.17

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    ACS Style

    T. S. Rekha; N. M. Nandini. Evaluation of Breast Neoplastic Lesions by Different Cytology Grading Methods. Sci. J. Clin. Med. 2015, 4(4-1), 26-30. doi: 10.11648/j.sjcm.s.2015040401.17

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    AMA Style

    T. S. Rekha, N. M. Nandini. Evaluation of Breast Neoplastic Lesions by Different Cytology Grading Methods. Sci J Clin Med. 2015;4(4-1):26-30. doi: 10.11648/j.sjcm.s.2015040401.17

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  • @article{10.11648/j.sjcm.s.2015040401.17,
      author = {T. S. Rekha and N. M. Nandini},
      title = {Evaluation of Breast Neoplastic Lesions by Different Cytology Grading Methods},
      journal = {Science Journal of Clinical Medicine},
      volume = {4},
      number = {4-1},
      pages = {26-30},
      doi = {10.11648/j.sjcm.s.2015040401.17},
      url = {https://doi.org/10.11648/j.sjcm.s.2015040401.17},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.s.2015040401.17},
      abstract = {Introduction: With the increase in the awareness of breast cancer among women, cases of lump in the breast has increased in outpatient department. Fine needle aspiration cytology (FNAC) is the easy, quick and cost effective technique of evaluating breast lump. Objective: The present study, evaluated and compared the modified Masood's cytology index (MCI) with various other cytology grading methods and histopathology. Result: Modified MCI has over all concordance rate of 86%, sensitivity of 86%, specificity of 50%, positive predictive value (PPV) of 93% and negative predictive value (NPV) of 30%. Multiple regression analysis revealed an r2 value of 60%, which was significant. The p-value of anisonucleosis, nucleoli and chromatin pattern were 0.001, 0.05 and 0.02 respectively, which was significant (p-value less than 0.05). Conclusion: Modified MCI will help the cytopathologist to accurately delineate both benign and malignant neoplastic breast lesions into respective categories. This in turn will help the treating surgeon to plan the treatment modality of the patients with lump in the breast. The study recommends that modified MCI method to be routinely incorporated for evaluation of all lump in the breast.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Evaluation of Breast Neoplastic Lesions by Different Cytology Grading Methods
    AU  - T. S. Rekha
    AU  - N. M. Nandini
    Y1  - 2015/08/03
    PY  - 2015
    N1  - https://doi.org/10.11648/j.sjcm.s.2015040401.17
    DO  - 10.11648/j.sjcm.s.2015040401.17
    T2  - Science Journal of Clinical Medicine
    JF  - Science Journal of Clinical Medicine
    JO  - Science Journal of Clinical Medicine
    SP  - 26
    EP  - 30
    PB  - Science Publishing Group
    SN  - 2327-2732
    UR  - https://doi.org/10.11648/j.sjcm.s.2015040401.17
    AB  - Introduction: With the increase in the awareness of breast cancer among women, cases of lump in the breast has increased in outpatient department. Fine needle aspiration cytology (FNAC) is the easy, quick and cost effective technique of evaluating breast lump. Objective: The present study, evaluated and compared the modified Masood's cytology index (MCI) with various other cytology grading methods and histopathology. Result: Modified MCI has over all concordance rate of 86%, sensitivity of 86%, specificity of 50%, positive predictive value (PPV) of 93% and negative predictive value (NPV) of 30%. Multiple regression analysis revealed an r2 value of 60%, which was significant. The p-value of anisonucleosis, nucleoli and chromatin pattern were 0.001, 0.05 and 0.02 respectively, which was significant (p-value less than 0.05). Conclusion: Modified MCI will help the cytopathologist to accurately delineate both benign and malignant neoplastic breast lesions into respective categories. This in turn will help the treating surgeon to plan the treatment modality of the patients with lump in the breast. The study recommends that modified MCI method to be routinely incorporated for evaluation of all lump in the breast.
    VL  - 4
    IS  - 4-1
    ER  - 

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Author Information
  • Department of Pathology, JSS Medical College, Constituent College of JSS University, Mysore, India

  • Department of Pathology, JSS Medical College, Constituent College of JSS University, Mysore, India

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