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Metastasis of Adrenocortical Carcinoma to Pericardial Fluid, Cytological Diagnosis (IHC) – A Case Report

Received: 1 July 2015     Accepted: 3 July 2015     Published: 3 August 2015
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Abstract

A 54 years male patient presenting with multiple complaints was found to have large pericardial effusion leading to tamponade. Radiological findings were suggestive of a right adrenal mass. Cytological evaluation of the pericardial fluid revealed features of malignant effusion. Adrenocortical origin of the malignant cells was confirmed by immunostaining with A103 antibody against Melan-A. Hence, identification of primary lesion and confirmation of diagnosis was achieved by cytology with the help of immunohistochemistry performed on the cell block obtained from the drained pericardial fluid.

Published in Science Journal of Clinical Medicine (Volume 4, Issue 4-1)

This article belongs to the Special Issue Latest Different Concepts of Gynaecology

DOI 10.11648/j.sjcm.s.2015040401.18
Page(s) 31-35
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Melan-A, Adrenocortical Carcinoma, Malignant Pericardial effusion, Cytology, Immunohistochemistry

References
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[2] Ng L, Libertino JM: Adrenocortical carcinoma: diagnosis, evaluation and treatment. J Urol , 169:5-11,2003.
[3] Nakata A, Yagi S, Oyama K, Kida H, Sugioka G: Adrenocortical carcinoma with a Giant Pericardial Mass. Internal Medicine,32:438 – 440, 1993.
[4] Ghorab, Zeina MD; Jorda, Merce MD, PhD; Ganjei, Parvin MD; Mehrdad MD: Melan A ( A103 ) Is Expressed in Adrenocortical Neoplasms but Not in Renal Cell and Hepatocellular Carcinomas. Applied immunohistochemistry and molecular morphology,11:330-333,2003.
[5] Brennan MF. Adrenocortical Carcinoma . CA Cancer J Clin,37:348-65,1987.
[6] Norton JA, Levin B, Jensen RT. Cancer of the endocrine system: the adrenal gland. DeVita VT Jr., Hellman S, Rosenberg SA (eds), Cancer: Principles and Practice of Oncology. Philadelphia, PA: JB Lippincott,1352-71,1993.
[7] Page DL, DeLellis RA, Hough AJ. Tumors of the adrenal (monograph) In: Atlas of Tumor Pathology, Washington D.C.: AFIP; 1986.
[8] Lutin JP, Cerdas S, Billiaud L, Thomas G, Gilhaume B, Bertagna X, Laudat MH, Louvel A, Chapuis Y and Blondeau P. Clinical features of adrenocortical carcinoma, prognostic factors, and the effect of mitotane therapy. N Engl J Med,322: 1195-1201,1990.
[9] Rosen B, Rozenman Y, Harpaz D: Extension of adrenocortical carcinoma into the right atrium - echocardiographic diagnosis: A case report. Cardiovascular Ultrasound, 1:5,2003.
[10] Shivakumar S. Udasimath; Surekha U. Arakeril; Mahesh H. Karigowdar; B. R. Yelikar: The Role of the Cell Block Method in the Diagnosis of Malignant Ascitic Fluid Effusions. JCDR:6(7)1280-1283,2012.
[11] David G. Meyers; Rayma E. Meyers; Thomas W. Prendergast: The Usefulness of Diagnostic Tests on Pericardial Fluid. Chest,111(5):1213-1221,1997.
[12] Zhang P.J. ,M.D.; Gnerga E.M.,M.D.;Tomaszewski J.E. ,M.D.; Pasha T.L.,B.S.; LiVolsi V.A., M.D. The Role oc Calretinin. Inhibin, Melan-A, BCL-2, and C-Kit in Differentiating Adrenal Cortical and Medullary Tumors: An Immunohistochemical Study. Mod Pathol, 16(6):591-597,2003.
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    Vasudha Nassa, Nandini N. M., Sushma K. L., Sapna Patel, Manjunath G. V. (2015). Metastasis of Adrenocortical Carcinoma to Pericardial Fluid, Cytological Diagnosis (IHC) – A Case Report. Science Journal of Clinical Medicine, 4(4-1), 31-35. https://doi.org/10.11648/j.sjcm.s.2015040401.18

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    ACS Style

    Vasudha Nassa; Nandini N. M.; Sushma K. L.; Sapna Patel; Manjunath G. V. Metastasis of Adrenocortical Carcinoma to Pericardial Fluid, Cytological Diagnosis (IHC) – A Case Report. Sci. J. Clin. Med. 2015, 4(4-1), 31-35. doi: 10.11648/j.sjcm.s.2015040401.18

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    AMA Style

    Vasudha Nassa, Nandini N. M., Sushma K. L., Sapna Patel, Manjunath G. V. Metastasis of Adrenocortical Carcinoma to Pericardial Fluid, Cytological Diagnosis (IHC) – A Case Report. Sci J Clin Med. 2015;4(4-1):31-35. doi: 10.11648/j.sjcm.s.2015040401.18

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  • @article{10.11648/j.sjcm.s.2015040401.18,
      author = {Vasudha Nassa and Nandini N. M. and Sushma K. L. and Sapna Patel and Manjunath G. V.},
      title = {Metastasis of Adrenocortical Carcinoma to Pericardial Fluid, Cytological Diagnosis (IHC) – A Case Report},
      journal = {Science Journal of Clinical Medicine},
      volume = {4},
      number = {4-1},
      pages = {31-35},
      doi = {10.11648/j.sjcm.s.2015040401.18},
      url = {https://doi.org/10.11648/j.sjcm.s.2015040401.18},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.s.2015040401.18},
      abstract = {A 54 years male patient presenting with multiple complaints was found to have large pericardial effusion leading to tamponade. Radiological findings were suggestive of a right adrenal mass. Cytological evaluation of the pericardial fluid revealed features of malignant effusion. Adrenocortical origin of the malignant cells was confirmed by immunostaining with A103 antibody against Melan-A. Hence, identification of primary lesion and confirmation of diagnosis was achieved by cytology with the help of immunohistochemistry performed on the cell block obtained from the drained pericardial fluid.},
     year = {2015}
    }
    

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    T1  - Metastasis of Adrenocortical Carcinoma to Pericardial Fluid, Cytological Diagnosis (IHC) – A Case Report
    AU  - Vasudha Nassa
    AU  - Nandini N. M.
    AU  - Sushma K. L.
    AU  - Sapna Patel
    AU  - Manjunath G. V.
    Y1  - 2015/08/03
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    N1  - https://doi.org/10.11648/j.sjcm.s.2015040401.18
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    T2  - Science Journal of Clinical Medicine
    JF  - Science Journal of Clinical Medicine
    JO  - Science Journal of Clinical Medicine
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    PB  - Science Publishing Group
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    UR  - https://doi.org/10.11648/j.sjcm.s.2015040401.18
    AB  - A 54 years male patient presenting with multiple complaints was found to have large pericardial effusion leading to tamponade. Radiological findings were suggestive of a right adrenal mass. Cytological evaluation of the pericardial fluid revealed features of malignant effusion. Adrenocortical origin of the malignant cells was confirmed by immunostaining with A103 antibody against Melan-A. Hence, identification of primary lesion and confirmation of diagnosis was achieved by cytology with the help of immunohistochemistry performed on the cell block obtained from the drained pericardial fluid.
    VL  - 4
    IS  - 4-1
    ER  - 

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Author Information
  • Department of Pathology, JSS Medical College, Constituent College of JSS University, Mysore,Karnataka, India

  • Department of Pathology, JSS Medical College, Constituent College of JSS University, Mysore,Karnataka, India

  • Department of Pathology, JSS Medical College, Constituent College of JSS University, Mysore,Karnataka, India

  • Department of Pathology, JSS Medical College, Constituent College of JSS University, Mysore,Karnataka, India

  • Department of Pathology, JSS Medical College, Constituent College of JSS University, Mysore,Karnataka, India

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