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Constitutional Pericentric Inversion of Chromosome 9 and Chronic Myeloid Leukemia

Received: 10 October 2014     Accepted: 6 November 2014     Published: 20 November 2014
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Abstract

In the present study, we screened the bone marrow chromosome database entries between March, 2004 and December, 2013 to identify cases with inv(9) along with t(9;22) variations. Our study recorded 2300 cases of confirmed CML (Ph positive), of which only 12 (0.52%) cases had inv(9) and t(9;22). The association between inv(9) and t(9;22) is not fully explored. Therefore more number of cases is required to shed light on its important role, if any, especially in bone-marrow transplantation and drug resistance.

Published in American Journal of Clinical and Experimental Medicine (Volume 2, Issue 6)
DOI 10.11648/j.ajcem.20140206.13
Page(s) 128-131
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Pericentric Inv (9), CML, t(9; 22), Bone-Marrow

References
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[2] S. Uehara, Y. Akai, Y. Takeyama, T. Takabayashi, K. Okumura, and A. Yajima. “Pericentric inversion of chromosome 9 in prenatal diagnosis and infertility”. Tohoku J Exp. Med. vol.166, pp. 417-427. 1992.
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[4] Y. Inayama, H. Yoneda, K. Fukushima, J. Sakai, H. Asba, and .T Skai. “Pericentric inversion of chromosome 9 with schizoaffective disorder”. Clin genet. vol.51, pp. 69-70, 1997.
[5] C. Milan, and L.Laberti. “Study of C-polymorphism of chromosome 1,9,16 in lymphocytes of patients with laryngeal carcinoma”. Boll Soc. Ital Biol Sper. vol. 72, pp.187-194, carcinoma”. Boll.Soc.Ital. Biol. Sper. Vol.72, pp.187-194,1996.
[6] T. Yasuhara, A. Okamoto , T. Kitagwa, T. Nikaido, T. Yoshimura, T. Vanaihara, S. Takakura, T. Tanaka, K. Ochiai and Y. Ohtake. “FGF7 like gene associated with pericentric inversion of chromosome 9 and FGF7 is involved in the development of ovarian cancer”. Int J Oncol. vol.26, pp. 1209 – 1216, 2005.
[7] M. A. Seabright. “A rapid banding technique for human chromosome”. Lancet. Vol. 2,pp. 971-972, 1971
[8] International System for Human Cytogenetics Nomenclature (ISCN), S. Karger Pbl. Inc. (2009).
[9] S.G.Lee, T.S.Park, G. Lim, K.A.Lee, J. Song and J.R.Choi. “Constitutional pericentric inversion and hematological disorders. A Korean tertiary Institution experience over eight years. Vol.40, pp.273-277, 2010.
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[12] T. S. Wan, S.K. Ma, and I.C.Chan. “Acquired pericentric inversion of chromosome 9 in essential thrombocytopenia”. Humn. Genet. Vol. 106, pp.669-670, 2000.
[13] Y.K.Keung, M.A. Knovich, B>L.Powell, D.H. Buss and M. Pettenanti. “Constitutional pericentric inversion of chromosome 9 and acute leukemia. Can. Genet. Cytogen. Vol.145, pp.82-85, 2003
[14] B. Suh, J. Song, J. Kim, T.S. Park and J. R. Choi. “Constitutional pericentric inversion 9 in Korean patients with chronic myelo- genous leukemia”. Kor.J. Lab. Med. Vol.30, pp. 218-223, 2010.
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  • APA Style

    Salil Vaniawala, Gadhia Pankaj. (2014). Constitutional Pericentric Inversion of Chromosome 9 and Chronic Myeloid Leukemia. American Journal of Clinical and Experimental Medicine, 2(6), 128-131. https://doi.org/10.11648/j.ajcem.20140206.13

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    ACS Style

    Salil Vaniawala; Gadhia Pankaj. Constitutional Pericentric Inversion of Chromosome 9 and Chronic Myeloid Leukemia. Am. J. Clin. Exp. Med. 2014, 2(6), 128-131. doi: 10.11648/j.ajcem.20140206.13

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    AMA Style

    Salil Vaniawala, Gadhia Pankaj. Constitutional Pericentric Inversion of Chromosome 9 and Chronic Myeloid Leukemia. Am J Clin Exp Med. 2014;2(6):128-131. doi: 10.11648/j.ajcem.20140206.13

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  • @article{10.11648/j.ajcem.20140206.13,
      author = {Salil Vaniawala and Gadhia Pankaj},
      title = {Constitutional Pericentric Inversion of Chromosome 9 and Chronic Myeloid Leukemia},
      journal = {American Journal of Clinical and Experimental Medicine},
      volume = {2},
      number = {6},
      pages = {128-131},
      doi = {10.11648/j.ajcem.20140206.13},
      url = {https://doi.org/10.11648/j.ajcem.20140206.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20140206.13},
      abstract = {In the present study, we screened the bone marrow chromosome database entries between March, 2004 and December, 2013 to identify cases with inv(9) along with t(9;22) variations. Our study recorded 2300 cases of confirmed CML (Ph positive), of which only 12 (0.52%) cases had inv(9) and t(9;22). The association between inv(9) and t(9;22) is not fully explored. Therefore more number of cases is required to shed light on its important role, if any, especially in bone-marrow transplantation and drug resistance.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - Constitutional Pericentric Inversion of Chromosome 9 and Chronic Myeloid Leukemia
    AU  - Salil Vaniawala
    AU  - Gadhia Pankaj
    Y1  - 2014/11/20
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    DO  - 10.11648/j.ajcem.20140206.13
    T2  - American Journal of Clinical and Experimental Medicine
    JF  - American Journal of Clinical and Experimental Medicine
    JO  - American Journal of Clinical and Experimental Medicine
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    PB  - Science Publishing Group
    SN  - 2330-8133
    UR  - https://doi.org/10.11648/j.ajcem.20140206.13
    AB  - In the present study, we screened the bone marrow chromosome database entries between March, 2004 and December, 2013 to identify cases with inv(9) along with t(9;22) variations. Our study recorded 2300 cases of confirmed CML (Ph positive), of which only 12 (0.52%) cases had inv(9) and t(9;22). The association between inv(9) and t(9;22) is not fully explored. Therefore more number of cases is required to shed light on its important role, if any, especially in bone-marrow transplantation and drug resistance.
    VL  - 2
    IS  - 6
    ER  - 

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Author Information
  • Molecular Cytogenetic Unit, S. N. Gene Laboratory and Research Centre, President Plaza-A , Near RTO circle, Surat-395001, India

  • P. K. Gadhia, Molecular Cytogenetic Unit, S. N. Gene Lab. and Research Centre, Near RTO circle, Surat – 395001. India

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